This article will take a research-based look at the specific benefits of the most popular individual supplements and how they can be taken to maximize gains.

The evidence to support the efficacy of bodybuilding supplementation is pretty compelling. Supplements including, protein powders, glutamine, creatine and amino acids (both branch chain and free-form) have been know to work for some time and many of the relatively newer ones including ZMA, pro-hormones, and micellar casein are showing great promise.

For supplementation to work, specific supplements need to be taken with optimal timing, in the right combinations. When this is achieved three things occur: anabolic drive is increased, workload capacity is improved and recovery time is decreased (Di Pasquale, 1997; Colgan,1993).

Any good bodybuilding program will emphasize diet, training and supplementation. It is well worth investing in a good range of supplements to give an edge to ones efforts in the gym. However, it can be a daunting task trying to decipher exactly how much of a particular supplement to take and when best to take it.

This article will take a research-based look at the specific benefits of the most popular individual supplements and how they can be taken to maximize gains.


Anabolic Drive

Dr. Mauro Di Pasquale says supplements help to maximize the bodies anabolic drive (the bodies ability to produce more muscle).

“Anabolic drive involves the natural production of testosterone, growth hormone, insulin-like growth factor 1, insulin, thyroid cortisol and other hormones and growth factors responsible for muscle growth and is enhanced through supplementation.”

Michael Colgan says anabolic drive is a precise synergy of nutritional, hormonal, and metabolic activities that completely control muscle growth.

“To enhance anabolic drive one should focus on supplements that act in a synergistic fashion to promote growth,” says Colgan.

Increasing the output of growth hormone is fundamental prerequisite to enhancing anabolic drive. Supplements to increase growth hormone include arginine and ornithine taken together in the absence of competing amino acids. The real key however is to stimulate the release of insulin-like growth factor 1 (IGF 1) as this is what travels to the muscles and causes them to grow.

Growth hormone release through arginine and ornithine does this to an extent but a new supplement shows great promise in terms of directly increasing the output of IGF 1 as well as free and total testosterone: an anabolic mineral support formula called ZMA which contains zinc, magnesium, vitamin B6 G-amino butyric acid, Mucuna Pruiens and LPG. One must bear in mind the importance of adequate neural levels of vitamin C before growth hormone will increase will have any effect.

In addition, studies have shown that potassium levels need to be adequate for optimal growth hormone, and IGF 1 release (Flyvbjerg, 1991). In recent years pro-hormones (steroid hormones able to increase the manufacture of testosterone) have saturated the market and studies have shown them to be effective at increasing free and total testosterone levels and enhancing growth like no other supplement.

Androstenedione (4-androsten-3, 17-dione) and 19-Norandrostenedione (19-Nor-4-androsten-3,17-dione) are two popular pro-hormones that have as their target hormones testosterone and 19-Norandrostenedione respectively.

Glutamine is also very effective in enhancing muscle growth due to its cell volumizing and nitrogen retentive properties (Lacy & Wilmore, 1990).

Creatine, wonder supplement from the 90s onward, has been shown also to increase lean muscle mass due to stimulated water retention, protein synthesis/hypertrophy and improved quality of training (Kreider, 1996).

HMB (the leucine metabolite) has been hypothesized to inhibit protein degradation during training which leads to increased muscle mass. However, more studies are needed to validate its efficacy.

Liver tablets are not as widely used as they once were but are still effective nevertheless. High in protein and rich in vitamins A, C, D, K, E and the entire B complex, iron, copper zinc, magnesium, selenium and chromium, liver tablets will undoubtedly enhance muscle growth if used in conjunction with a sound diet, and supplement program.


Training Enhancement

Ability to produce effort in the gym is absolutely essential if one is to realize gains in muscle. Irrespective of how well managed the diet and supplement program is, lack of correct training intensity will produce insufficient results.

The best supplements for energy production include: creatine, which increases power output and muscle torque while delaying fatigue, caffeine, which minimizes fatigue and increases stamina, and glutamine, which has been shown to prevent immunosuppression (Kreider, 1996) and enhance glycogen function (glycogen sparring) during training (Van Hall, 2000).

Other recommended supplements include the amino acids alanine and arginine, and vitamin C as well as chromium taken in combination so as to work in a synergistic fashion.

“The best supplements for energy production include... creatine, caffeine, glutamine, alanine, arginine and more..."

Ribose is another great supplement when aiming to increase training intensity. In fact ribose, a 5-carbon naturally occurring sugar, is essential for ATP (A mitochondrial energy source) production. In essence, ribose supplementation allows one to train longer and recover quicker.


Recovery

Finally, if training intensity, diet and supplementation is sufficient but recovery has fallen short, results will not be forthcoming. Recovery between sets and sessions is crucial to success and if not addressed will lead to overtraining. Muscle loss as opposed to muscle gain will occur.

The Best Supplements For Recovery Purposes Include:

  • Protein powders (whey and micellar casein) for muscle tissue repair
  • Glutamine for restored immune system function and increased protein synthesis, and nitrogen retention
  • Branch chain amino acids (BCAA’s) as they are metabolized in the muscle and help to build new muscle proteins.

Supplemental protein consumption post-workout has been shown to promote a more favourable anabolic hormone profile according to Kreider (1996). Whey protein is faster acting than the slow digesting micellar casein protein and therefore more effectively assimilated following training, allowing greater protein synthesis facilitation and enhanced recovery. It has also been shown to have a perfect combination of amino acids.

Glutamine, in addition to its muscle building and energy enhancing properties, has an positive influence on ammonia suppression and muscle micro-trauma healing. BCAA’s are thought to promote recovery by decreasing exercise-induced protein degradation and serum muscle enzyme efflux possible by promoting and anti-catabolic hormonal profile (Kreider, 1996).

“Protein synthesis is contingent upon a number of factors including insulin activity and supplementing with chromium has shown to enhance insulin activity and protein synthesis as a result (Colgan, 1993)."

The above supplements have been scientifically shown to work but this does not necessarily mean they will have the desired result if wrongly taken. The most effective way to use these supplements is at specific times and in the correct combinations. The following are recommended to increase anabolic drive and training capacity and enhance recovery.

Pre-Workout Supplement Stack (30-60 minutes prior to training):

Or

  • Ribose: Three grams - [ Learn More ]
  • Creatine: Five grams

During Training:

  • Glutamine: Five grams sipped with water.

Post-Workout Supplement Stack (Directly after training):

  • Whey protein: One scoop containing at least 20 grams of protein.
  • Glutamine: Five grams.
  • BCAA’s: L-Valine: 400mg, L-Leucine, 400mg, L-Isoleucine, 200mg - [ Learn More ]

20-45 Minutes After Training:

  • Creatine: Five grams mixed with grape juice.
  • Ribose: Three grams.
  • Micellar Casein protein: 30 grams - [ Learn More ]

With Meals:

  • Liver tablets: Two tablets (60 grain), twice per day. - [ Learn More ]
  • Vitamin C: One gram, twice per day.

Before Bed

  • Ribose: Three grams on non-training days.

Or

  • ZMA: Recommended dose on an empty stomach on training days. - [ Learn More ]

Or

  • Micellar Casein protein: 30 grams.


Find all your supplements at discounted prices at our store.

References

  1. Flyvbjerg. (1991). Evidence that potassium deficiency induces growth retardation through reduced circulating levels of growth hormone and insulin-like growth factor 1: Metabolism, 40: 769-775.
  2. Lacey JM, Wilmore DW. Is glutamine a conditionally essential amino acid? Nutr Rev. 1990;48:297-309.
  3. Van Hall et al (2000) The Effect of Free Glutamine and Peptide Ingestion on the Rate of Muscle Glycogen Resynthesis in Man, International Journal of Sports Med 21, 25-30
  4. Kreider, R. (1996). Dietary Supplements and the Promotion of Muscle Growth with Resistance Training. Baylor University [Online]
  5. Di Pasquale, M. (1997). High-Tech supplementation. Muscle and Fitness. Weider Health and Fitness PTY LTD.
  6. Colgan, M.(1993). Optimum Sports Nutrition. Advanced Research Press: USA.


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