Bodybuilding.com - Creatine Ethyl Ester Information and Product Listing! Creatine Ethyl Ester FAQ!

Creatine Ethyl Ester HCL (CEE) is creatine monohydrate with an ester attached. Esters are organic compounds that are formed by esterification - the reaction of carboxylic acid and alcohols.

What does it do and what scientific studies give evidence to support this?

Regular creatine monohydrate has been shown effective at increasing lean muscle mass^1,2,3,4, muscle strength^5,6 and athletic performance.^7,8

However, regular creatine monohydrate is absorbed poorly by the body - and its effectiveness is dependant upon the cells ability to absorb it. The poor absorption rate of regular creatine monohydrate requires the creatine user to ingest large dosages of creatine to achieve desired effect.

Because creatine draws water to the cell, and because most ingested creatine monohydrate is not absorbed, unabsorbed creatine will sit outside of the target cell with the water, and this will result in the "creatine bloat."

Long-term clinical studies have proven that creatine monohydrate is safe for use by persons free of medical complication⁹, but why would you want to ingest more creatine monohydrate than you have to simply because your creatine is inefficient?

Creatine ethyl ester is creatine monohydrate with an ester attached. The attachment of an ester is significant, because esters are found in the fat tissue of animals. But, why is this important? What role does this have in the absorption of creatine?

All substances that you put into your body will affect its operation. There are three ways that substances can affect a cells operation. They are:

Ligand binding to protein receptor sites.
Secondary messenger / metabotropic systems
Passive permeation of the cell wall via lipids

When a substance enters the body and affects the bodies operation, it is known as a ligand. The soma and dendrites of the cell have protein receptor sites to which ligands can bind. The process of a ligand binding with a receptor site is akin to a lock and key: only keys of a certain shape work with certain locks. When they work and cause the cells stimulation they are called agonists. When they block the cell from functioning they are called antagonists.

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When a ligand binds with the receptor site of a target cell, the cell, in the simplest of cases, changes its shape, opens up its ion channels and changes its function. In so-called "secondary messenger" or metabotropic cells, the ligand binds with the receptor site and an internal protein known as a g-protein is released. This released protein then binds to an internal site inside of the cell, and then the cell changes its behavior by opening its ion channels. Cells that operate in this way are known as metabotropic cells because their operation requires metabolic energy.

Passive permeation is a process that describes the diffusion of a substance across a cell membrane through the use of lipids as transport mechanisms. Because no "work" is being done by the cell in this model, this model is called passive permeation.

Creatine monohydrate utilizes lipids to permeate the cell wall and enter the cell. Because of this, the esterification of creatine, and the presence of esters in animal fat tissue, becomes significant.

Creatine monohydrate is semi-lipopholic. This means that it inefficiently uses fat as a transport mechanism. The esterification of substances will increase their lipopholic abilities, and thus esterified creatine will use fat more efficiently to permeate the cell wall and exert its effects upon cellular function than its unesterified creatine monohydrate counterpart.

This means, simply, that not only will dosage requirements be lower, but the absorption of esterified creatine will be increased and the infamous "creatine bloat" will be eliminated!

Who needs it and what are some symptoms of deficiency?

Creatine Ethyl Ester can benefit persons of all ages, as it displays the same benefits as regular creatine monohydrate.

Is Creatine Ethyl Ester real?

Much controversy has been generated over creatine ethyl ester. Companies and individuals with a financial interest in promoting creatine monohydrate products have attempted to discredit creatine ethyl ester. Some companies have even gone so far as to commission laboratory reports that show that creatine ethyl ester is not real.

Included with this page is one such report, and also included are two COA's - certificates of analysis - proving that creatine ethyl ester is real. These are included so that you, the consumer, can make up your own mind - so that you can base your choices upon the power of information.

The one report that states that creatine ethyl ester is fake was commissioned by an industry company with an interest in discrediting creatine ethyl ester. The two certificates of analysis included show that CEE is real and was done on raw source product and conducted by people with no financial interest in the promotion of creatine ethyl ester.

The esterification of creatine is chemically possible and not hard to conceive. Those who claim that CEE is fake are denying obvious science and are cheating the consumer.

To view these reports click here!

How much should be taken? Are there any side effects?

Strictly adhere to label recommendations.

No side effects have been reported in scientific literature.

REFERENCES

View references here.

Republished from Clayton South's Health Facts.

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Name - Link Servings Mg Per Serving Price Per Gram Lowest Price

ALRI Cr2, 240 Capsules 80 2000 $0.15 $23.99
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Axis Labs Creatine Ethyl Ester, 240 Capsules 80 2250 $0.13 $22.95
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Axis Labs Creatine Ethyl Ester, 360 Capsules + 10% Free 120 2250 $0.11 $28.99
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Higher Power CE3, 240 Capsules 60 3000 $0.08 $14.99
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Higher Power Creatine Ethyl Ester, 1000 Grams 400 2500 $0.04 $36.95
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Higher Power Creatine Ethyl Ester, 500 Grams 200 2500 $0.04 $19.99
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IronMagLabs CEE, 240 Capsules 60 3000 $0.13 $22.99
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Labrada CreaLean2, 120 Capsules 40 2100 $0.21 $17.99
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Mega-Pro CEE, 240 Capsules 80 2250 $0.08 $13.99
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Millennium Sport CEE HCL 3000, 240 Capsules 60 3000 $0.13 $22.99
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MRI CE2, 180 Capsules 90 1400 $0.52 $64.99
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NRG-X Labs CEE 3000, 240 Capsules 60 3000 $0.13 $23.95
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PrimaForce CEE, 250 Grams 125 2000 $0.08 $19.99
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PrimaForce CEE, 500 Grams 250 2000 $0.06 $28.99
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PrimaForce CEE Caps, 240 Sci-Caps 60 2000 $0.17 $19.99
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Pro-Rx Labs Muscle Pump, 240 Capsules 60 3000 $0.17 $29.99
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SciFit C E Ester 1000, 1000 Grams 400 1000 $0.10 $38.89
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Six Star Muscle Professional Strength Creatine, 60 Capsules 30 2000 $0.33 $19.99
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SNS Creatine E2, 120 Capsules 60 1500 $0.16 $14.49
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SNS Creatine E2, 240 Capsules 120 1500 $0.12 $21.99
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Sports Nutrition International Creatine Ethyl Ester, 240 Capsules 80 2250 $0.13 $22.79
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Supplement Direct Creatine Ethyl Ester HCL, 250 Grams 100 2500 $0.05 $12.99
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* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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