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Designer Supplements N.O. Limits

180 Capsules $44.95 $29.89 [Order]  In Stock Other Designer Supplements Products About Designer Supplements What's In It? 180 Capsules Supplement Facts Serving Size6Capsule Servings Per Container30 Amount Per Serving % Daily Value L-Arginine Ethyl Ester DiHCL 1.5g L-Lysine Ethyl Ester DiHCL 1g L-Ornithine Ethyl Ester DiHCL 500mg Citrulline Ethyl Ester HCL 500mg NAC(N-Acetyl Cysteine) 500mg Folic Acid 400mcg * Daily Value not established Other Ingredients Microcrystalline Cellulose, Magnesium Stearate, Croscarmellose Sodium, Aerosil 200 Directions: As a dietary supplement, take 6 capsules approximately 30 to 45 minutes prior to your workout. Take with at least 12-16 ounces of water and continue to drink fluids prior to and during your workout. Warnings: For use as a dietary supplement only, by healthy adults the age of 18 and over. Do not exceed the daily recommended serving size, and do not use for more than 60 consecutive days. Use this product responsibly; always consult a physician before using this or any other dietary supplement. * These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Designer Supplements Presents: N.O. Limits Superior Cell Volumization This works well with: >Straight Drol >S-Drol >BCAA+G 6000 Caps >NAC Skin-Tearing Pumps and Enhanced Nutrient Uptake! Through the promotion of blood flow and positive nutrient partitioning, Nitric Oxide (NO) has found an elite place amongst bodybuilding and fitness enthusiasts looking to improve their physique. While some products merely do an adequate job of accomplishing this goal, the ideal NO product can produce a proverbial “skin-tearing” pump that provides the perfect physical and mental motivation for training; a product that makes you feel unstoppable in the gym. It is with this concept in mind that Designer Supplements introduces N.O. Limits™, the evolutionary next step in Nitric Oxide signalling products. Avoiding the trappings of unnecessary ingredients and proprietary blends, N.O. Limits™ is comprised of four primary ingredients with attached ethyl esters to enhance effectiveness, plus antioxidants to enhance safety and long term efficacy. Additionally, while the pump alone may be impressive enough for some, N.O. Limits™ combines Arginine Ethyl Ester with Lysine Ethyl Ester for the first time ever in an NO product to maximize natural growth hormone (GH) secretion. Now, before we explain exactly why increased blood flow, increased nutrient uptake, long-lasting pumps, and maximized GH secretion can make an athlete feel as though there are N.O. Limits™ to what he or she can do, it is first our duty to explain how. N.O. Limits™, N.O. Nonsense Traditional NO-boosting products use the NO precursor L-Arginine or a varied structure of this amino acid in order to provide substrate for NO conversion. N.O. Limits™ not only provides the substrate using the new ethyl ester technology, it also utilizes compounds that control Nitric Oxide production while also providing anti-oxidants to control free radical release that Nitric Oxide and physical exercise can cause. By paying close attention to these details, N.O. Limits™ aims to not only prolong the efficacy of nitric oxide in users, but also potentially correct the fact that NO-boosters do not work in all users. What is Nitric Oxide? Nitric Oxide (NO) is a highly important signalling molecule in the body. Interestingly, it is a gas, and even more interesting is that it is also a free radical. While major research has recently indicated that NO is intimately related to brain, stomach, kidney, liver and lung function, the major interest bodybuilders and athletes have in NO is that it regulates blood flow and can influence nutrient uptake. Initially referred to as the Endothelium-Derived Relaxing Factor (EDRF), NO achieves its most tangible effect by causing the outer wall (the smooth muscle) of the blood vessel to relax and dilate. More specifically, NO binds to an enzyme known as guanylyl cyclase which catalyzes the conversion of Guanosine Triphosphate (GTP) to 3’,5’-cyclic Guanosine Monophosphate (cGMP). It is the cGMP that signals the smooth muscle to relax. The net result of this reaction allows more nutrient-rich blood to travel through the artery thereby causing the effect commonly known as the “pump”. Not only is the pump mentally motivating, but there is also speculation that it may promote increased protein synthesis in the stressed muscle, and may increase creatine synthesis. On a similar note, very early scientific research into Arginine itself suggested that it was required for creatine synthesis, possibly due to it’s effect at raising Nitric Oxide. More recent research also suggests that NO is involved in satellite cell proliferation which is one of the preliminary processes that must occur to initiate muscle repair and growth. With regards to nutrient uptake, it was initially suggested that NO promoted nutrient uptake independently of the insulin signalling pathway, maybe as part of insulin-independent nutrient uptake (from muscle contractions, such as physical exercise). However more recent research indicates that nutrient uptake promoted by NO may be independent of both the insulin and contraction signalling pathways. While still speculative, this mechanism is extremely exciting as it suggests that NO-boosting products are more than just superficial and may actually help promote muscle growth beyond assistance in mental motivation to break through plateaus. Nitric Oxide Synthesis NO is typically created in the endothelium (a lining of the blood vessel) as a by-product of Citrulline production after Arginine combines with oxygen with the help of a group of enzymes called Nitric Oxide Synthase or NOS (there are three identified types of NOS depending upon where the conversion is taking place). This is referred to as the L-Arginine- Nitric Oxide Pathway. Keeping this mechanism in mind, providing the body with more substrate in the way of Arginine can help boost this reaction and as history has shown, any good NO-boosting product fundamentally uses this as a basis for their product. While this is all fine and dandy, for those who like to think outside of the box and look further into what is actually occurring within the body, a superior formula can be created. In order to accomplish this, the amino acid Citrulline can not be ignored. Studies indicate that not only does citrulline appear to boost levels of Arginine in the body, it may also boost levels higher than taking Arginine itself. While this mechanism has not yet been fully elucidated, it may very well be due to the fact that Arginine appears to be heavily metabolized in the intestine and by the liver before it has full access to the bloodstream. Citrulline vs. Ammonia Citrulline is an amino acid that is metabolized in the kidneys in order to create Arginine which can then be made available to other tissues throughout the body. In reality, the fact that Citrulline is the rate-limiting factor for Arginine synthesis in the kidneys11 makes it almost illogical to produce an NO-boosting formula that does not include a source of Citrulline. In addition to this fact, Citrulline’s relationship to Arginine and Ornithine is extremely significant in that all three are important intermediates in the process known as the Urea cycle; a process which occurs in the kidneys and is critically important for regular body function through removal of highly toxic ammonia from the blood stream. Ammonia is a by-product of nitrogen breakdown that accumulates due to a variety of bodily processes, including amino acid digestion. By increasing metabolic rate and therefore amino acid breakdown, physical exercise produces a great deal of ammonia which may build-up. It is actually this build-up of ammonia and subsequent change in cellular pH that is partially responsible for the “burn” experienced during intense exercise or high-rep sets. When the Urea cycle is unable to keep up with nitrates, their build-up induces a metabolic acidosis which can inhibit energy production, reduce recovery, and hinder athletic performance significantly. Citrulline helps negate this effect by promoting the kidney to reabsorb bicarbonates which acts as a buffer against lactic acidosis, thereby helping to avoid fatigue and promoting endurance. By supplying Arginine, Citrulline and Ornithine together, N.O. Limits™ ensures that there are no rate-limiting factors for this process and keeps the cycle going in overdrive in order to supply more NO for positive effects on the “pump”, endurance, and nutrient uptake. Folic Acid Folic acid has been shown to enhance the NOS isoform found in the endothelium (called ‘eNOS’). It is thought to do this via its effects on a major co-factor involved in arginine-to-Nitric Oxide conversion, tetrahydrobiopterin (BH4). Folic acid is a major component for NO signalling, and a deficiency can result in many problems, including vascular dysfunction. Arginine, Lysine & Growth Hormone Secretion Lysine is included in N.O. Limits™ due to its ability to promote human Growth Hormone (hGH) secretions, specifically when combined with Arginine. In a step never taken by any other company before, N.O. Limits™ uses this combination in their ethyl ester form for increased bioavailability. As an added benefit, research also indicates that Arginine appears to be capable of reducing the inhibitory action IGF-1 has on hGH release. As hGH is part of many metabolic functions of the body that relate to anabolic activity, this fact poses further exciting possibilities that a well designed NO-product might be more than “just the pump.” While questions may be raised about how effective or significant this rise in hGH may be, its effects upon stimulating protein synthesis, bone strengthening and lipolysis (fat burning) are certainly welcomed. Glutathione and NO Production As stated earlier, due to NO being a free radical, including antioxidants in an NO-boosting formula is an excellent idea. Glutathione is the body’s best natural anti-oxidant and unfortunately, NO production and nitrate disposal diminish the body’s glutathione reserves18. Additionally, it is speculated that the oxidative stress induced by NO production causes further glutathione depletion. It is theorized that as glutathione levels drop, the body’s own NO production capacity lowers, inducing tolerance to nitrates. This process may explain why some people simply do not respond to NO-boosting products and why others only respond for a few days before becoming tolerant. While other products either ignore this fact or try circumventing the effect in a roundabout manner, N.O. Limits™ goes straight to the source by supplying a compound that supports the body’s glutathione producing capabilities - Cysteine - in the form of N-Acetyl-Cysteine (NAC). In addition to this, the acetyl group can be donated from NAC to be plugged into the Krebs Cycle where it can go towards ATP production. Free Radicals In addition to glutathione depletion, physical exercise increases free radical generation as by-products of metabolic processes that are stepped-up to meet demand for energy. Unfortunately, NO and one of the primary free radicals provoked by exercise, superoxide, have strong attraction and their combination produces peroxynitrite species. Peroxynitrite, along with other free radicals, exert detrimental effects on protein synthesis, insulin signaling and general health while also stimulating synthesis of the chemical Asymmetric Dimethylarginine (ADMA), which inhibits the eNOS isoform. While all of this may sound negative, beneficial effects are noted as long as NO production is kept in balance with the increase in free radicals. While the body is quite adept at doing this on its own, N.O. Limits™ offers additional assistance through the addition of proven anti-oxidants. N.O. Limits™ caters to the balance with the inclusion of NAC. Additionally, for those who desire that extra level of assurance, R-Alpha Lipoic Acid in the form of Glucophase XR™ or the soon-to-be-released Insutrol™ can prove to be a useful adjunct in that it may promote activity of the NOS in addition to its well studied anti-oxidant effect against free radicals. Summary In summary, N.O. Limits™ is the best choice of NO-promotion available today, and is excellent for: Promoting workout “pumps” Improving blood flow Increasing nutrient uptake Maximizing hGH release Positive Mental motivation N.O. Limits™ can be stacked with XCEED™ to form the perfect pre-workout cocktail that will maximize your performance as you train, and promote your recovery as you rest. The addition of Replenish™ post workout along with Glucophase XR™ confers added benefit in terms of nutrient partitioning, active recovery, and maximal cellular signalling to ensure the best results of each and every workout. Going to the gym should be about maximum results for your effort and it is for this reason that you should set N.O. Limits™ to your expectations. References Schmidt HH, Walter U. NO at work. Cell. 1994 Sep 23;78(6):919-25. Moncada S, Higgs A. The L-arginine-nitric oxide pathway. N Engl J Med. 1993 Dec 30;329(27):2002-12. Paddon-Jones D, Borsheim E, Wolfe RR. Potential ergogenic effects of arginine and creatine supplementation. J Nutr. 2004 Oct;134(10 Suppl):2888S-2894S; discussion 2895S. Barbul A. Arginine: biochemistry, physiology, and therapeutic implications. JPEN J Parenter Enteral Nutr. 1986 Mar-Apr;10(2):227-38. Foster G. L, Schoenheimer R, Rittenberg D. Studies in protein metabolism V. The utilization of ammonia for amino acid and creatine formation in animals. J. Biol. Chem. 1939 127: 319-327. Tatsumi R, Hattori A, Ikeuchi Y, Anderson JE, Allen RE. Release of hepatocyte growth factor from mechanically stretched skeletal muscle satellite cells and role of pH and nitric oxide. Mol Biol Cell. 2002 Aug;13(8):2909-18. Tatsumi R, Liu X, Pulido A, Morales M, Sakata T, Dial S, Hattori A, Ikeuchi Y, Allen RE. Satellite cell activation in stretched skeletal muscle and the role of nitric oxide and hepatocyte growth factor. Am J Physiol Cell Physiol. 2006 Jun;290(6):C1487-94. Balon TW, Nadler JL. Evidence that nitric oxide increases glucose transport in skeletal muscle. J Appl Physiol. 1997 Jan;82(1):359-63. Higaki Y, Hirshman MF, Fujii N, Goodyear LJ. Nitric oxide increases glucose uptake through a mechanism that is distinct from the insulin and contraction pathways in rat skeletal muscle. 2001 Feb;50(2):241-7. Yearick ES, Nadeau RG. Serum amino acid response to isocaloric test meals. Am J Clin Nutr. 1967 Apr;20(4):338-44. Dhanakoti SN, Brosnan JT, Herzberg GR, Brosnan ME. Renal arginine synthesis: studies in vitro and in vivo. Am J Physiol. 1990 Sep;259(3 Pt 1):E437-42. Castillo L, Chapman TE, Yu YM, Ajami A, Burke JF, Young VR. Dietary arginine uptake by the splanchnic region in adult humans. Am J Physiol. 1993 Oct;265(4 Pt 1):E532-9. Wilkerson JE, Batterton DL, Horvath SM. Exercise-induced changes in blood ammonia levels in humans. Eur J Appl Physiol Occup Physiol. 1977 Dec 22;37(4):255-63. Callis A, Magnan de Bornier B, Serrano JJ, Bellet H, Saumade R. Activity of citrulline malate on acid-base balance and blood ammonia and amino acid levels. Study in the animal and in man. Arzneimittelforschung. 1991 Jun;41(6):660-3. Suminski RR, Robertson RJ, Goss FL, Arslanian S, Kang J, DaSilva S, Utter AC, Metz KF. Acute effect of amino acid ingestion and resistance exercise on plasma growth hormone concentration in young men. Int J Sport Nutr. 1997 Mar;7(1):48-60. Isidori A, Lo Monaco A, Cappa M. A study of growth hormone release in man after oral administration of amino acids. Curr Med Res Opin. 1981;7(7):475-81. Gianotti L, Maccario M, Lanfranco F, Ramunni J, Di Vito L, Grottoli S, Muller EE, Ghigo E, Arvat E. Arginine counteracts the inhibitory effect of recombinant human insulin-like growth factor I on the somatotroph responsiveness to growth hormone-releasing hormone in humans. J Clin Endocrinol Metab. 2000 Oct;85(10):3604-8. Schwemmer M, Bassenge E. New approaches to overcome tolerance to nitrates. Cardiovasc Drugs Ther. 2003 Mar;17(2):159-73. Berges A, Van Nassauw L, Bosmans J, Timmermans JP, Vrints C. Role of nitric oxide and oxidative stress in ischaemic myocardial injury and preconditioning. Acta Cardiol. 2003 Apr;58(2):119-32. Das UN. Folic acid says NO to vascular... Nutrition. 2003 Jul-Aug;19(7-8):686-92. Mayer B, Hemmens B. Biosynthesis and action of nitric oxide in mammalian cells. Trends Biochem Sci. 1997 Dec;22(12):477-81. Bassenge E, Fink B. Tolerance to nitrates and simultaneous upregulation of platelet activity prevented by enhancing antioxidant state. Naunyn Schmiedebergs Arch Pharmacol. 1996 Feb;353(3):363-7. Smith AR, Hagen TM. Vascular endothelial dysfunction in aging: loss of Akt-dependent endothelial nitric oxide synthase phosphorylation and partial restoration by (R)-alphalipoic acid. Biochem Soc Trans. 2003 Dec;31(Pt 6):1447-9. Bridgeman MM, Marsden M, MacNee W, Flenley DC, Ryle AP. Cysteine and glutathione concentrations in plasma and bronchoalveolar lavage fluid after treatment with Nacetylcysteine. Thorax. 1991 Jan;46(1):39-42. Stroes ES, van Faassen EE, Yo M, Martasek P, Boer P, Govers R, Rabelink TJ. Folic acid reverts dysfunction of endothelial nitric oxide synthase. Circ Res. 2000 Jun 9;86(11):1129-34. Wilmink HW, Stroes ES, Erkelens WD, Gerritsen WB, Wever R, Banga JD, Rabelink TJ. Influence of folic acid on postprandial endothelial dysfunction. Arterioscler Thromb Vasc Biol. 2000 Jan;20(1):185-8. Das UN. Folic acid says NO to vascular... Nutrition. 2003 Jul-Aug;19(7-8):686-92. Verhaar MC, Wever RM, Kastelein JJ, van Dam T, Koomans HA, Rabelink TJ. 5-methyltetrahydrofolate, the active form of folic acid, restores endothelial function in familial hypercholesterolemia. Circulation. 1998 Jan 27;97(3):237-41. Symons JD, Rutledge JC, Simonsen U, Pattathu RA. Vascular dysfunction produced by hyperhomocysteinemia is more severe in the presence of low folate. Am J Physiol Heart Circ Physiol. 2006 Page 4 Jan;290(1):H181-91. Order today using our 100% secure server and get it at the lowest prices in the world with our fast, inexpensive 2 - 3 day shipping! NOBODY beats our overall price! 180 Capsules $44.95 $29.89 [Order]  In Stock Buy Fast. Feel Secure. Pay Later!sm Details Learn more about L-Arginine. Check out other Muscle Building Products.