Advanced Muscle & Energy System For Maximum Gains!
So advanced that it's being copied, but never duplicated, by the major supplement companies. Creatine Advantage maximizes and enhances the anabolic and energy enhancing effects of creatine. It's the most advanced, and copied, creatine formula on the market today.
While creatine monohydrate has been shown to enhance athletic performance, and to
increase strength and muscle mass, these effects are enhanced in Creatine Advantage by
stacking creatine with other ingredients. Our formula not only contains the highest quality,
pure crystalline creatine monohydrate so that it mixes instantly and leave's no chalky taste,
but we've also added a host of other natural ingredients that make our formula much more
effective and versatile than any other creatine products on the market.
Creatine monohydrate is absorbed fairly well if just mixed with water. Using carbs increases
insulin secretion and thus creatine utilization. However, basically taking in a few ounces or
more of sugar to your creatine or even adding creatine to a protein shake will do just as much
for creatine absorption and utilization as the creatine products that are out there now.
However, with the right formulation you can accomplish a lot more.
To understand why you need a number of synergistic ingredients besides creatine to
maximize the energy systems in the body it's important to know some basics on creatine
metabolism. Creatine is used by the body to make phosphocreatine, and the
phosphocreatine is a high energy source that functions to replenish ATP (the primary energy
source in the body) when it's depleted.
The body needs about 2 grams of creatine a day to account for the amount of creatine that is
metabolized to creatinine irreversibly. The creatinine is then excreted in the body. Part of this
turnover can be replaced through exogenous sources of creatine in foods, especially meat
and fish, and of course by supplementing with creatine monohydrate or creatine phosphate
(the two most common forms available in supplements with the monohydrate being by far the
most widely available). The remainder is derived via endogenous synthesis from the
precursors arginine, glycine and methionine. Both the creatine and the creatine precursors
(all three are in the glutamine peptides mix) are supplied in Creatine Advantage.
It's also important that you provide the body with the means, preferably by breaking down and
oxidizing body fat, to increase energy levels so that phosphocreatine can be made from
creatine plus phosphate. And it's important to simultaneously maximize the effects of insulin,
GH, and IGF-I, which is difficult to do using carbs and sugars, not only to synergistically
maximize the levels of these anabolic hormones, but also so that the creatine is most
efficiently used.
Creatine Advantage doesn't overwhelm the body with creatine, since less than 3 grams per
day is all that's needed to maximize creatine cellular levels - the usual doses of creatine used
by athletes are mostly excreted1 (as urinary creatine and a small amount of creatinine) and
secondly the use of excessive amounts for long periods of time may be counter productive as
far as potential adverse effects. However, at the same time Creatine Advantage maximizes
phosphocreatine and ATP production (the TCA cycle intermediates and the AMP), and
protein synthesis (the amino acid content and glutamine peptides).
Added amino acids and dipeptides and other essential boosters allow an increase in the
absorption and utilization of creatine and increase the volumizing, anticatabolic and anabolic
effect of the formula. The added energy ingredients and precursors make Creatine
Advantage the ultimate creatine and energy mix, one that will maximize muscle mass and
performance.
Increased Synthesis of PC and ATP
Creatine Advantage contains all the necessary products for the synthesis of both high energy
phosphate compounds creatine phosphate and ATP, and for the efficient salvage of ATP
after it's been metabolically degraded, including:
- Inorganic phosphorus and phosphates - also important for normalizing and regulating thyroid hormone.
- Creatine
- Inosine
- Ribose
It also contains the following nutrients to facilitate the glycolytic and TCA cycle energy
processes:
- Biotin - a cofactor in many energy reactions involving glycogenolytic, glycolytic, TCA and anapleurotic enzymes.
- Magnesium - which has also been shown to increase energy systems, insulin sensitivity, protein synthesis and serum testosterone, GH and IGF-I levels.
- Calcium - which has been shown to facilitate muscle contraction and decreasing fatigue).
- Potassium, the transport of which is linked to aerobic glycolysis.
Increasing TCA Flux and ATP Synthesis
Creatine Advantage maximizes ATP production (as I mentioned above ATP is the main
energy source in the body - the function of phosphocreatine is to replenish ATP, so it makes
sense to increase ATP levels as well). It contains a proprietary blend of several ingredients
that maximizes mitochondrial anapleurotic flux in the TCA cycle resulting in increased ATP
production and increased energy availability for protein synthesis and other functions,
including the formation of phosphocreatine. These ingredients, including several anapleurotic
direct and indirect TCA cycle intermediates (such as aspartate, citrate, malate, fumarate,
succinate, and the various anapleurotic and the various amino acids, including the
branched chain amino acids, glutamate, glutamine, and other amino acids present in the
glutamine peptides hydrolysate), impact on TCA flux and maximize mitochondrial
metabolism, increase aerobic ATP production, and enhance insulin and growth hormone/IGFI
secretion and formation.
The overall increase in anapleurotic flux produces an increase in aerobic energy production,
insulin secretion, and protein synthesis, and results in an increased adaptive response, a
surge in skeletal muscle cell growth, increased fat loss, and improved recovery.
Adenosine monophosphate (AMP), one of the ingredients in Creatine Advantage, activates
AMPK (AMP-activated protein kinase), which in turn, among other effects such as increasing
insulin sensitivity in skeletal muscle,2 decreases the concentration of malonyl-coA in
peripheral tissues, (as does exercise BTW) and thus decreases triglyceride accumulation and
increases fatty acid oxidation.3 The overall response to all of this is also an increase in energy
output, which under conditions of energy deprivation, such as when you're trying to lose
weight and/or body fat, increases fat oxidation further.
Insulin Boosting System
Creatine Advantage has a low carbohydrate based insulin boosting system (glutamine in the
form of glutamine peptides - more stable in liquid form and more effective than free
glutamine) and compounds to increase insulin sensitivity (chromium, histidine - which also
provides intracellular buffering to stimulate anaerobic energy formation, taurine4 - which also
has significant antioxidant and protective effects, stimulates growth hormone secretion and
increases cell volume, and alpha lipoic acid - which is also an excellent antioxidant) and
thus make the insulin more effective. All of these compounds increase the boosting effect that
insulin has on intramuscular creatine phosphate levels. For example a recent study found
that co-ingestion of alpha-lipoic acid with creatine can enhance muscle total creatine content
as compared to the ingestion of creatine and sucrose or creatine alone.5
As well, there is a significant increase in insulin sensitivity and/or insulin secretion, when a
protein hydrolysate, such as the glutamine peptides, is combined with creatine.6 Sodium is
also important for increasing creatine uptake in muscle and some studies has been found to
be important for creatine uptake into relatively insulin insensitive muscles such as the
soleus.7
Creatine Advantage Also Contains:
1. Glutamine peptides, which have anabolic (increases protein synthesis and muscle mass)
and anticatabolic (decrease muscle breakdown) effects, above those normally associated
with glutamine, as the peptides themselves have some physiological effects. Also the peptide
form is better absorbed than free glutamine that is not peptide bonded.
As well, the glutamine in the glutamine peptides:
- Regulates protein synthesis
- Increases both aerobic and anaerobic energy systems
- Has beneficial effects on the immune system
- Increases insulin sensitivity when a protein hydrolysate is combined with creatine.8
2. An advanced cell volumizing formula that results not only in increases in protein
synthesis and an anabolic effect, but an increased transport of creatine inside muscle and
other cells. This formula includes:
- Glutamine
- Taurine
- Potassium
- Sodium
- Creatine itself which has significant volumizing effects.
3. Branched Chain Amino Acids
Increased intracellular concentrations of branched chain amino acids (leucine, valine and
isoleusine) stimulate formation of acetyl-coenzyme (CoA) and succinyl-CoA, thus increasing
both glycolytic and anapleurotic flux and aerobic and anaerobic energy production. All three,
but especially leucine, have a synergistic effect with creatine on increasing protein synthesis.
What's Not in Creatine Advantage
Almost as important as what's in Creatine Advantage, is what's not in it. For example,
guanidinopropionic acid (GPA), an ingredient that is used in some creatine products, is not an
ingredient as it seems that its use can decrease creatine levels in heart muscle cells and
likely muscle cells.9 As well, in keeping with a lower carb approach, which besides decreasing
fat oxidation also decreases GH and IGF-I levels, Creatine Advantage only contains 1.5
grams of carbs per 10 grams serving - just enough to maximize creatine uptake into muscle
cells, but not enough to have counter productive effects.
Safety of Long-Term Creatine Intake
Studies have shown that the long term use of creatine does not have any significant side
effects, such as an increase in muscle cramping or injuries, nor does it impact on the body's
ability to manufacture creatine endogenously once the creatine is discontinued.10,11 Muscle
creatine levels usually return to normal within 4 weeks.12
References
- Vandenberghe K, Goris M, Van Hecke P, Van Leemputte M, Vangerven L, Hespel P. Long-term creatine
intake is beneficial to muscle performance during resistance training. J Appl Physiol. 1997 Dec;83(6):2055-63.
- Ruderman NB, Cacicedo JM, Itani S, et al. Malonyl-CoA and AMP-activated protein kinase (AMPK): possible
links between insulin resistance in muscle and early endothelial cell damage in... Biochem Soc Trans.
2003 Feb;31(Pt 1):202-6. Review.
- Ruderman NB, Saha AK, Kraegen EW. Minireview: malonyl CoA, AMP-activated protein kinase, and adiposity.
Endocrinology. 2003 Dec;144(12):5166-71. Review.
- Nandhini ATA & Anuradha CV. Taurine modulates kallikrein activity and glucose metabolism in insulin resistant
rats. Amino Acids 200; 222, 27-38.
- Burke DG, Chilibeck PD, Parise G, Tarnopolsky MA, Candow DG. Effect of alpha-lipoic acid combined with
creatine monohydrate on human skeletal muscle creatine and phosphagen concentration. Int J Sport Nutr
Exerc Metab. 2003 Sep;13(3):294-302.
- Derave W, Eijnde BO, Verbessem P, Ramaekers M, Van Leemputte M, Richter EA, Hespel P. Combined
creatine and protein supplementation in conjunction with resistance training promotes muscle GLUT-4 content
and glucose tolerance in humans. J Appl Physiol. 2003 May;94(5):1910-6. Epub 2003 Jan 10.
- Willott CA, Young ME, Leighton B, Kemp GJ, Boehm EA, Radda GK, Clarke K. Creatine uptake in isolated
soleus muscle: kinetics and dependence on sodium, but not on insulin. Acta Physiol Scand. 1999
Jun;166(2):99-104.
- Derave W, Eijnde BO, Verbessem P, Ramaekers M, Van Leemputte M, Richter EA, Hespel P. Combined
creatine and protein supplementation in conjunction with resistance training promotes muscle GLUT-4 content
and glucose tolerance in humans. J Appl Physiol. 2003 May;94(5):1910-6. Epub 2003 Jan 10.
- Boehm E, Chan S, Monfared M, Wallimann T, Clarke K, Neubauer S. Creatine transporter activity and content
in the rat heart supplemented by and depleted of creatine. Am J Physiol Endocrinol Metab. 2003
Feb;284(2):E399-406.
- Kreider RB.Species-specific responses to creatine supplementation. Am J Physiol Regul Integr Comp Physiol
2003; 285: R725-R726.
- Greenwood M, Kreider RB, Melton C, Rasmussen C, Lancaster S, Cantler E, Milnor P, Almada A. Creatine
supplementation during college football training does not increase the incidence of cramping or injury. Mol Cell
Biochem 2003; 244: 83-88.
- Vandenberghe K, Goris M, Van Hecke P, Van Leemputte M, Vangerven L, Hespel P. Long-term creatine
intake is beneficial to muscle performance during resistance training. J Appl Physiol. 1997 Dec;83(6):2055-63.
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